- Virginia Tech -15 at Wake Forest
- Miami (FL) -7.3 at Virginia
- Tennessee -0.9 vs. Missouri
- South Carolina -24.4 vs. South Alabama
- Ball State -16.8 vs. Eastern Michigan
- Michigan State -20.3 vs. Rutgers
- Nebraska -7.1 vs. Minnesota
- Mississippi State -30.2 vs. Vanderbilt
- Ohio State -34.2 vs. Indiana
- Michigan -8.2 vs. Maryland
- Oklahoma -24.8 vs. Kansas
- Pittsburgh -8.7 vs. Syracuse
- Northwestern -3.4 at Purdue
- Central Michigan -3.8 vs. Western Michigan
- East Carolina -14.8 vs. Tulane
- Florida State -19.9 vs. Boston College
- Penn State -4.6 at Illinois
- Wisconsin -10.0 at Iowa
- Marshall -21.5 at UAB
- Colorado State -21.8 vs. New Mexico
- Western Kentucky -4.8 vs. UTSA
- Boise State -12.7 at Wyoming
- Texas Tech -2.5 at Iowa State
- Ole Miss -7.1 at Arkansas
- Baylor -27.0 vs. Oklahoma State
- Houston -22.4 vs. Tulsa
- Oregon -32.9 vs. Colorado
- Notre Dame -1.8 vs. Louisville
- North Texas -2.3 vs. Florida International
- Stanford -8.2 at California
- Utah -6.4 vs. Arizona
- Washington -5.3 vs. Oregon State
- Clemson -39.9 vs. Georgia State
- Arizona State -17.2 vs. Washington State
- Memphis -19.3 vs. South Florida
- Middle Tennessee -4.4 vs. Florida Atlantic
- Cincinnati -7.5 at Connecticut
- Louisiana-Monroe -7.4 at New Mexico State
- UCF -26.1 vs. Southern Methodist
- UCLA -9.0 vs. USC
- Nevada -5.2 vs. Fresno State
- Hawaii -5.0 vs. UNLV